- 赤芍的化学成分和药理作用研究进展被引量：241收藏
- 作者：陆小华 马骁 王建 朱云 周宗元 陈哲 赵艳玲 王伽伯
- 机构：成都中医药大学药学院;解放军第三○二医院全军中药研究所
- 来源：《中草药》 2015
- 关键词：赤芍 芍药总苷 鞣质 黄酮类 保肝 抗肿瘤
- 摘要：赤芍为临床常用中药,具有清热凉血、散瘀止痛的功效。其主要化学活性成分为芍药总苷,尚含鞣质类、黄酮类、挥发油类等成分。因具有保肝、抗肿瘤、神经保护、心脏保护、抗血栓、抗氧化等多种显著的药理作用而成为近年研究的热点。查阅近1...
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- 麦冬化学成分及药理作用研究进展被引量：37收藏
- 作者：彭婉 马骁 王建 曾南 董泰玮 李雷 李敏
- 机构：成都中医药大学药学院
- 来源：《中草药》 2018
- 关键词：麦冬 甾体皂苷类 高异黄酮类 多糖类 降血糖 保护心血管系统 增强免疫力
- 摘要：麦冬在中国分布广泛,资源丰富,是一种利用价值很高的药用植物,具有养阴生津、润肺清心的功效。现代研究发现麦冬的化学成分主要包括甾体皂苷类、高异黄酮类、多糖类等;具有降血糖、保护心血管系统、增强免疫力、抗皮肤衰老、抗炎、抗肿...
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- 穿山甲的研究进展被引量：27收藏
- 作者：周宗元 王建 马骁
- 机构：成都中医药大学药学院、中药材标准化教育部重点实验室、中药资源系统研究与开发利用省部共建国家重点实验室培育基地
- 来源：《中药与临床》 2014
- 关键词：穿山甲 化学 炮制 药理 临床
- 摘要：笔者收集整理穿山甲现代相关文献，通过对该药的主要炮制方法、大类化学成分、主要药理作用特点和临床主治等领域的要点进行分析研究，发现该药采用机制炮制方法优于传统砂烫等方法；其主要含蛋白质、氨基酸等成分；有扩张血管、促进血液循...
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- Curcumin Protects against CCl4-Induced Liver Fibrosis in Rats by Inhibiting HIF-1 alpha Through an ERK-Dependent Pathway被引量：25收藏
- 作者：Zhao, Yanling Ma, Xiao Wang, Jiabo He, Xuan Hu, Yan Zhang, Ping Wang, Ruilin Li, Ruisheng Gong, Man Luo, Shengqiang Xiao, Xiaohe
- 机构：302 Mil Hosp China;Chengdu Univ Tradit Chinese Med;Sichuan Univ;302 Mil Hosp China;302 Mil Hosp China
- 来源：MOLECULES 2014
- 关键词：curcumin carbon tetrachloride liver fibrosis hypoxia inducible factor
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- Spectrum-Effect Relationships Between Chemical Fingerprints and Antibacterial Effects of Lonicerae Japonicae Flos and Lonicerae Flos Base on UPLC and Microcalorimetry被引量：22收藏
- 作者：Shi, Zhilong Liu, Zhenjie Liu, Chunsheng Wu, Mingquan Su, Haibin Ma, Xiao Zang, Yimei Wang, Jiabo Zhao, Yanling Xiao, Xiaohe
- 机构：Chengdu Univ Tradit Chinese Med;302 Hosp Peoples Liberat Army;Beijing Univ Chinese Med;302 Hosp Peoples Liberat Army
- 来源：FRONTIERS IN PHARMACOLOGY 2016
- 关键词：Lonicerae Japonicae Flos antibacterial microcalorimetry spectrum-effect relationships UPLC
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- The Therapeutic Efficacy and Safety of Compound Kushen Injection Combined with Transarterial Chemoembolization in Unresectable Hepatocellular Carcinoma: An Update Systematic Review and Meta-Analysis被引量：21收藏
- 作者：Ma, Xiao Li, Rui-Sheng Wang, Jian Huang, Yin-Qiu Li, Peng-Yan Wang, Ji Su, Hai-Bin Wang, Rui-Lin Zhang, Ya-Ming Liu, Hong-Hong Zhang, Cong-En Ma, Zhi-Jie Wang, Jia-Bo Zhao, Yan-Ling Xiao, Xiao-He
- 机构：Peoples Liberat Army;Chengdu Univ Tradit Chinese Med;Peoples Liberat Army;Peoples Liberat Army;Sichuan Univ
- 来源：FRONTIERS IN PHARMACOLOGY 2016
- 关键词：Compound Kushen Injection transarterial chemoembolization unresectable hepatocellular carcinoma meta-analysis systematic review
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- Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1 alpha through mTOR-dependent pathway被引量：20收藏
- 作者：Zhao, Yanling Ma, Xiao Wang, Jiabo Zhu, Yun Li, Ruisheng Wang, Jian He, Xuan Shan, Limei Wang, Ruilin Wang, Lifu Li, Yonggang Xiao, Xiaohe
- 机构：302 Mil Hosp China;Chengdu Univ Tradit Chinese Med;302 Mil Hosp China;Sichuan Univ;302 Mil Hosp China
- 来源：FITOTERAPIA 2014
- 关键词：Paeoniflorin Carbon tetrachloride Liver fibrosis Hypoxia inducible factor
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- 厚朴炙远志炮制品的安神和祛痰作用研究被引量：17收藏
- 作者：马骁 王建 黄聪 罗凤娟 郑新光 曾南 夏厚林
- 机构：成都中医药大学药学院·教育部重点实验室中药标准化实验室
- 来源：《中药药理与临床》 2013
- 关键词：厚朴炙远志 镇静催眠 镇咳祛痰 远志 厚朴
- 摘要：目的：考察厚朴炙远志炮制品对小鼠的镇静催眠、镇咳祛痰作用的影响。方法：采用戊巴比妥钠协同小鼠催眠实验与小鼠自主活动实验,对比炮制品与单味远志、单味厚朴之间的镇静催眠药效;采用氨水诱导法致小鼠咳嗽实验和小鼠气管酚红排泌的祛...
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- Urine metabolomics study on the liver injury in rats induced by raw and processed Polygonum multiflorum integrated with pattern recognition and pathways analysis被引量：15收藏
- 作者：Zhang, Cong-en Niu, Ming Li, Qi Zhao, Yan-ling Ma, Zhi-jie Xiong, Yin Dong, Xiao-ping Li, Rui-yu Feng, Wu-wen Dong, Qing Ma, Xiao Zhu, Yun Zou, Zheng-sheng Cao, Jun-ling Wang, Jia-bo Xiao, Xiao-he
- 机构：302 Mil Hosp;Chengdu Univ Tradit Chinese Med;Capital Med Univ;302 Mil Hosp;Beijing Univ Chinese Med
- 来源：JOURNAL OF ETHNOPHARMACOLOGY 2016
- 关键词：Metabolomics Urine Liver injury Polygonum multiflorum L. Processed products LC-MS
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- Paeonia lactiflora Pall. protects against ANIT-induced cholestasis by activating Nrf2 via PI3K/Akt signaling pathway被引量：15收藏
- 作者：Ma, Xiao Zhao, Yan-ling Zhu, Yun Chen, Zhe Wang, Jia-bo Li, Rui-yu Chen, Chang Wei, Shi-zhang Li, Jian-yu Liu, Bing Wang, Rui-lin Li, Yong-gang Wang, Li-fu Xiao, Xiao-he
- 机构：Chengdu Univ Tradit Chinese Med;Peoples Liberat Army;Peoples Liberat Army;Peoples Liberat Army;Univ Hong Kong
- 来源：DRUG DESIGN DEVELOPMENT AND THERAPY 2015
- 关键词：Paeonia lactiflora Pall. cholestatic hepatitis antioxidation Nrf2 Akt
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- Serum Metabolomic Profiling in a Rat Model Reveals Protective Function of Paeoniflorin Against ANIT Induced Cholestasis被引量：15收藏
- 作者：Chen, Zhe Zhu, Yun Zhao, Yanling Ma, Xiao Niu, Ming Wang, Jiabo Su, Haibin Wang, Ruilin Li, Jianyu Liu, Liping Wei, Zhenman Zhao, Qingguo Chen, Hongge Xiao, Xiaohe
- 机构：302 Hosp Peoples Liberat Army;Chengdu Univ Tradit Chinese Med;302 Hosp Peoples Liberat Army;302 Hosp Peoples Liberat Army;302 Hosp Peoples Liberat Army
- 来源：PHYTOTHERAPY RESEARCH 2016
- 关键词：metabolomics cholestasis paeoniflorin pattern recognition approaches mechanism
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- Metabolomics Coupled with Multivariate Data and Pathway Analysis on Potential Biomarkers in Cholestasis and Intervention Effect of Paeonia lactiflora Pall被引量：14收藏
- 作者：Ma, Xiao Chi, Yong-Hui Niu, Ming Zhu, Yun Zhao, Yan-Ling Chen, Zhe Wang, Jia-Bo Zhang, Cong-En Li, Jian-Yu Wang, Li-Fu Gong, Man Wei, Shi-Zhang Chen, Chang Zhang, Lu Wu, Ming-Quan Xiao, Xiao-He
- 机构：302 Mil Hosp China;Chengdu Univ Tradit Chinese Med;Capital Med Univ;302 Mil Hosp China;302 Mil Hosp China
- 来源：FRONTIERS IN PHARMACOLOGY 2016
- 关键词：Paeonia lactiflora Pall. cholestasis metabolomics bile acid secretion biomarker
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- Paeoniflorin ameliorates ANIT-induced cholestasis by activating Nrf2 through an PI3K/Akt-dependent pathway in rats被引量：12收藏
- 作者：Chen, Zhe Ma, Xiao Zhu, Yun Zhao, Yanling Wang, Jiabo Li, Ruisheng Chen, Chang Wei, Shizhang Jiao, Wenjuan Zhang, Yaming Li, Jianyu Wang, Lifu Wang, Ruilin Liu, Honghong Shen, Honghui Xiao, Xiaohe
- 机构：Chengdu Univ Tradit Chinese Med;302 Hosp Peoples Liberat Army;302 Hosp Peoples Liberat Army;302 Hosp Peoples Liberat Army;302 Hosp Peoples Liberat Army
- 来源：PHYTOTHERAPY RESEARCH 2015
- 关键词：paeoniflorin cholestasis glutathione PI3K Akt pathway Nrf2
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- Large Dosage of Chishao in Formulae for Cholestatic Hepatitis: A Systematic Review and Meta-Analysis被引量：11收藏
- 作者：Ma, Xiao Wang, Ji He, Xuan Zhao, Yanling Wang, Jiabo Zhang, Ping Zhu, Yun Zhong, Lin Zheng, Quanfu Xiao, Xiaohe
- 机构：Chengdu Univ Tradit Chinese Med;302 Hosp Peoples Liberat Army;Sichuan Univ;Sichuan Univ;302 Hosp Peoples Liberat Army
- 来源：EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2014
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- Untargeted Metabolomics Reveals Dose-Response Characteristics for Effect of Rhubarb in a Rat Model of Cholestasis被引量：11收藏
- 作者：Zhang, Cong-En Niu, Ming Li, Rui-Yu Feng, Wu-Wen Ma, Xiao Dong, Qin Ma, Zhi-Jie Li, Guang-Quan Meng, Ya-Kun Wang, Ya Yin, Ping He, Lan-Zhi Li, Yu-Meng Tan, Peng Zhao, Yan-Ling Wang, Jia-Bo Dong, Xiao-Ping Xiao, Xiao-He
- 机构：Chengdu Univ Tradit Chinese Med;302 Mil Hosp;Capital Med Univ
- 来源：FRONTIERS IN PHARMACOLOGY 2016
- 关键词：metabolomics cholestasis rhubarb dose response pathway analysis
- 质疑
- 四味芳香开窍药的挥发性成分对缺血缺氧PC12细胞及细胞内Ca^(2+)的影响被引量：10收藏
- 作者：王丹丹 王建 彭颖 王茜 马骁 唐丹霞 夏厚林 曾南
- 机构：成都中医药大学教育部重点实验室中药标准化实验室
- 来源：《西安交通大学学报：医学版》 2012
- 关键词：四味芳香开窍药 挥发性成分 连二亚硫酸钠 PC12细胞 Ca2+
- 摘要：目的研究四味芳香开窍药的挥发性成分对连二亚硫酸钠(Na2S2O4)致PC12细胞缺血缺氧损伤及细胞内Ca2+的影响。方法体外实验采用5mmol/L的Na2S2O4导致PC12细胞缺血缺氧性损伤,然后观测细胞形态;用二甲基...
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- 余甘子果实化学成分及现代药理研究进展被引量：9收藏
- 作者：聂东 马骁 田徽
- 机构：绵阳师范学院科技处;成都中医药大学药学院中药教研室
- 来源：《绵阳师范学院学报》 2012
- 关键词：余甘子 活性成分 药理
- 摘要：余甘子作为药食两用的传统习用民族药物，营养、药效物质明确，安全性高，药理作用广泛，对病原微生物、肿瘤有良好的抑制作用，能抗氧化、抗疲劳、抗衰老，同时能提高免疫，保护肝脏及心脑血管健康等。该文通过对余甘子化学成分、药理作用...
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- Yinchenhao decoction in the treatment of cholestasis: A systematic review and meta-analysis被引量：7收藏
- 作者：Chen, Zhe Ma, Xiao Zhao, Yanling Wang, Jiabo Zhang, Yaming Li, Jianyu Wang, Ruilin Zhu, Yun Wang, Lifu Xiao, Xiaohe
- 机构：China Mil Inst Chinese Med;Chengdu Univ Tradit Chinese Med;302 Mil Hosp China
- 来源：JOURNAL OF ETHNOPHARMACOLOGY 2015
- 关键词：Cholestasis Yinchenhao decoction Meta-analysis Efficacy Safety
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- Microcalorimetry and turbidimetry to investigate the anti-bacterial activities of five fractions from the leaves of Dracontomelon dao on P-aeruginosa被引量：7收藏
- 作者：Wu, Mingquan Qu, Fen Zhao, Yanling Wang, Jiabo Su, Haibin Chen, Chang Zhang, Chenglong Guo, Yanlei Zhang, Ping Ma, Xiao Yang, Zhirui Zhang, Yaming Xiao, Xiaohe
- 机构：Chengdu Univ Tradit Chinese Med;302 Hosp Peoples Liberat Army;302 Mil Hosp;302 Mil Hosp China;302 Mil Hosp
- 来源：JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY 2016
- 关键词：Leaves of Dracontomelon dao Anti-P. aeruginosa Microcalorimetry Turbidimetry
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- Meta-Analysis for Clinical Evaluation of Xingnaojing Injection for the Treatment of Cerebral Infarction被引量：6收藏
- 作者：Ma, Xiao Yang, Yu X. Chen, Nian Xie, Qian Wang, Tao He, Xuan Wang, Jian
- 机构：Chengdu Univ Tradit Chinese Med;Xindu Dist Shibantan Publ Hosp
- 来源：FRONTIERS IN PHARMACOLOGY 2017
- 关键词：Xingnaojing injection cerebral infarction meta-analysis systematic review clinical evaluation
- 质疑
- Paeoniflorin ameliorates cholestasis via regulating hepatic transporters and suppressing inflammation in ANIT-fed rats被引量：6收藏
- 作者：Zhao, Yanling He, Xuan Ma, Xiao Wen, Jianxia Li, Pengyan Wang, Jiabo Li, Ruisheng Zhu, Yun Wei, Shizhang Li, Haotian Zhou, Xuelin Li, Kun Liu, Honghong Xiao, Xiaohe
- 机构：Hosp Peoples Liberat Army;Xindu Dist Shibantan Publ Hosp;Chengdu Univ Tradit Chinese Med
- 来源：BIOMEDICINE & PHARMACOTHERAPY 2017
- 关键词：Paeoniflorin Cholestasis NF-kappa B NTCP BSEP MRP2
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- 浅析“有故无殒,亦无殒”思想的科学内涵被引量：6收藏
- 作者：马骁 何璇 刘甜甜 陈哲 王建
- 机构：成都中医药大学药学院;四川大学生物治疗国家重点实验室
- 来源：《中药与临床》 2014
- 关键词：有故无殒 药效差异 机体耐受性 药代动力学特征 中药理论
- 摘要：＂有故无殒,亦无殒＂原指妊娠妇女在＂大积大聚＂状态下,可以适度合理使用大热大寒或峻猛药物达到治疗效果,同时也不会对孕妇及胎儿造成影响;但应中病即止,切勿因过度用药伤及孕妇及胎儿。现今其科学内涵已引申到生理病理用药差别的各...
- 质疑
- The protective roles of L-borneolum, D-borneolum and synthetic borneol in cerebral ischaemia via modulation of the neurovascular unit被引量：5收藏
- 作者：Dong, Taiwei Chen, Nian Ma, Xiao Wang, Jian Wen, Jing Xie, Qian Ma, Rong
- 机构：Chengdu Univ Tradit Chinese Med
- 来源：BIOMEDICINE & PHARMACOTHERAPY 2018
- 关键词：Borneol pMCAO Cerebral ischaemia Neurovascular unit
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- Large dose means significant effect - dose and effect relationship of Chi-Dan-Tui-Huang decoction on alpha-naphthylisothiocyanate-induced cholestatic hepatitis in rats被引量：5收藏
- 作者：Zhao, Yanling Ma, Xiao Wang, Jiabo Wen, Ruiqing Jia, Lei Zhu, Yun Li, Ruisheng Wang, Ruilin Li, Jianyu Wang, Lifu Li, Yonggang Xiao, Xiaohe
- 机构：302 Mil Hosp China;Chengdu Univ Tradit Chinese Med;Beijing Haidian Dist Inst Drug Control;Univ Hong Kong;302 Mil Hosp China
- 来源：BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 2015
- 关键词：Chi-Dan-Tui-Huang decoction Radix Paeoniae Rubra Cholestatic hepatitis
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- Study on hot property differences of Aconiti Lateralis Radix Praeparata and its compatibility with different ginger processed products based on bio-thermodynamics被引量：4收藏
- 作者：Chen, Zhe Zhao, Yanling Liu, Shuxian Zheng, Quanfu Liu, Tiantian Ma, Xiao Zhang, Ping Li, Ruisheng Wang, Lifu Li, Yonggang Zhang, Yaming Xiao, Xiaohe
- 机构：Chengdu Univ Tradit Chinese Med;302 Hosp Peoples Liberat Army
- 来源：JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY 2015
- 关键词：Ginger processed products Aconiti Lateralis Radix Praeparata Hot property differences Bio-thermodynamics
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- Antibacterial effect of different extracts from Wikstroemia indica on Escherichia coli based on microcalorimetry coupled with agar dilution method被引量：4收藏
- 作者：Chen, Chang Qu, Fen Wang, Jian Xia, Xinhua Wang, Jiabo Chen, Zhe Ma, Xiao Wei, Shizhang Zhang, Yaming Li, Jianyu Gong, Man Wang, Ruilin Liu, Honghong Yang, Zhirui Li, Yonggang Zhao, Yanling Xiao, Xiaohe
- 机构：Chengdu Univ Tradit Chinese Med;302 Hosp Peoples Liberat Army;302 Hosp Peoples Liberat Army;Hunan Univ Tradit Chinese Med;302 Hosp Peoples Liberat Army
- 来源：JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY 2016
- 关键词：Wikstroemia indica Anti-E. coli Bioactive fraction Microcalorimetry Agar dilution method
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- Paeoniflorin attenuates ANIT-induced cholestasis by inhibiting apoptosis in vivo via mitochondria-dependent pathway被引量：4收藏
- 作者：Zhou, Hou-Qin Liu, Wei Wang, Jian Huang, Yin-Qiu Li, Peng-Yan Zhu, Yun Wang, Jia-Bo Ma, Xiao Li, Rui-Sheng Wei, Shi-Zhang Li, Kun Li, Hao-Tian Li, Jian-Yu Xiao, Xiao-He Zhao, Yan-Ling
- 机构：Chengdu Univ Tradit Chinese Med;302 Mil Hosp China;302 Mil Hosp China;302 Mil Hosp China;Peoples Liberat Army
- 来源：BIOMEDICINE & PHARMACOTHERAPY 2017
- 关键词：Cholestasis Peaoniflorin ANIT Mitochondria signaling pathway Apoptosis
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- 远志-厚朴配伍对厚朴酚、和厚朴酚胃肠代谢的影响被引量：4收藏
- 作者：罗凤娟 王建 马骁 黄聪 田徽 郑新光 夏厚林
- 机构：成都中医药大学药学院
- 来源：《中国实验方剂学杂志》 2013
- 关键词：远志配厚朴 HPLC 胃液-肠液-血浆 厚朴酚 和厚朴酚
- 摘要：目的：研究远志配厚朴对大鼠在胃液-肠液-血浆中不同时间厚朴酚、和厚朴酚含量的影响。方法：利用甲醇沉淀蛋白处理胃、肠液及血浆样品,采用HPLC测定,色谱条件为Synergi Hydro-RP C18色谱柱（4.6 mm×2...
- 质疑
- Shexiang Baoxin Pills as an Adjuvant Treatment for Chronic Heart Failure: A System Review and Meta-Analysis被引量：4收藏
- 作者：Dong, Taiwei Wang, Jian Ma, Xiao Ma, Rong Wen, Jianxia Chen, Nian Xie, Qian
- 机构：Chengdu Univ Tradit Chinese Med
- 来源：EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2018
- 质疑
- Therapeutic Efficacy and Safety of Paeoniae Radix Rubra Formulae in Relieving Hyperbilirubinemia Induced by Viral Hepatitis: A Meta-Analysis被引量：4收藏
- 作者：Huang, Yin-Qiu Ma, Xiao Wang, Jian Zhao, Yan-Ling Wang, Jia-Bo Chen, Zhe Zhu, Yun Shan, Li-Mei Wei, Shi-Zhang Wang, Ji Xiao, Xiao-He
- 机构：Chengdu Univ Tradit Chinese Med;302 Mil Hosp China;Peoples Liberat Army;Peoples Liberat Army;Sichuan Univ
- 来源：FRONTIERS IN PHARMACOLOGY 2016
- 关键词：Paeoniae Radix Rubra formulae efficacy and safety meta-analysis hyperbilirubinemia viral hepatitis high dose Paeoniae Radix Rubra
- 质疑
