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Puerarin: A Review of Pharmacological Effects

文献类型:期刊文献

英文题名:Puerarin: A Review of Pharmacological Effects

作者:Zhou, Yan-Xi[1,2];Zhang, Hong[2];Peng, Cheng[1]

第一作者:周彦希;Zhou, Yan-Xi

通讯作者:|[1063353b7fdd3156aab86]彭成;

机构:[1]Chengdu Univ Tradit Chinese Med, Coll Pharm, Minist Educ, Key Lab Standardizat Chinese Herbal Med, Chengdu 610075, Peoples R China;[2]Second Mil Med Univ, Sch Pharm, Dept Med Bot, Shanghai 200433, Peoples R China

第一机构:成都中医药大学药学院

通讯机构:|[106336d1d673712fc3af1]成都中医药大学药学院;[10633]成都中医药大学;

年份:2014

卷号:28

期号:7

起止页码:961-975

外文期刊名:PHYTOTHERAPY RESEARCH

收录:WOS:【SCI-EXPANDED(收录号:WOS:000339518800003)】;

基金:This work was supported by the Open Research Fund of State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources.

语种:英文

外文关键词:puerarin; Pueraria lobata; pharmacology

摘要:Puerarin is the major bioactive ingredient isolated from the root of the Pueraria lobata (Willd.) Ohwi, which is well known as Gegen (Chinese name) in traditional Chinese medicine. As the most abundant secondary metabolite, puerarin was isolated from Gegen in the late 1950s. Since then, its pharmacological properties have been extensively investigated. It is available in common foods and is used in alternative medicine. It has been widely used in the treatment of cardiovascular and cerebrovascular diseases, diabetes and diabetic complications, osteonecrosis, Parkinson's disease, Alzheimer's disease, endometriosis, and cancer. The beneficial effects of puerarin on the various medicinal purposes may be due to its wide spectrum of pharmacological properties such as vasodilation, cardioprotection, neuroprotection, antioxidant, anticancer, antiinflammation, alleviating pain, promoting bone formation, inhibiting alcohol intake, and attenuating insulin resistance. However, the direct molecular mechanisms and targets remain unclear. This review provides a comprehensive summary of the pharmacological effects of puerarin. Copyright (C) 2013 John Wiley & Sons, Ltd.

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