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白芷挥发油镇痛、镇静作用和身体依赖性研究    

Studies on Analgesic and Sendative Effects and Physical Dependence of Essential Oil of Radix Angelicae Dahuricae

文献类型:期刊文献

中文题名:白芷挥发油镇痛、镇静作用和身体依赖性研究

英文题名:Studies on Analgesic and Sendative Effects and Physical Dependence of Essential Oil of Radix Angelicae Dahuricae

作者:聂红[1];沈映君[2];吴俊梅[2];覃仁安[2];任永欣[2]

第一作者:聂红

机构:[1]南京中医药大学博士后流动站,南京210029;[2]成都中医药大学,成都610075;

第一机构:南京中医药大学博士后流动站,南京210029

年份:2002

卷号:13

期号:4

起止页码:221-223

中文期刊名:中药新药与临床药理

外文期刊名:Traditional Chinese Drug Research & Clinical Pharmacology

收录:CSCD:【CSCD2011_2012】;CSTPCD;

语种:中文

中文关键词:白芷挥发油;药理学;镇痛;药物作用;镇静;物质依赖

外文关键词:essential oil of radix angelicae dahuricae/pharmacology ; Analgesia/drug effects ; Sedation /drug effects ; Substance dependence ; Mice

摘要:目的观察白芷挥发油(Essential oil of Radix Angelicae dahuricae,EOAD)的镇痛、镇静作用和身体依赖性.方法采用扭体法、热板法、辐射热刺激法、大鼠甩尾法观察EOAD的镇痛作用;用小鼠跳跃反应试验、小鼠竖尾反应实验观察EOAD的身体依赖性,并用热板法考察其耐受性;采用程控自主活动箱观察EOAD对小鼠自主活动的影响.结果EOAD对物理、化学等伤害性刺激的镇痛作用确切;小鼠跳跃反应试验表明,吗啡组小鼠出现显著的跳跃反应,而EOAD组则无;小鼠竖尾反应试验表明EOAD组小鼠未出现竖尾反应;EOAD对小鼠的自主活动具有显著的抑制效应.结论EOAD的镇痛、镇静作用明确且对小鼠无身体依赖性作用.
Objective: To investigate the analgesic and sedatire effects and physical dependence effects of essential oil of Radix angelicae dahuricae (EOAD).Methods : Analgesic effect in rats and mice was observed by body-torsion, hot-plate, radiate-hot and tail-flicking method. Meanwhile, the physical dependence and tolerance, free movement of mice were examined by jumping, tail-erecting, hot-plate method and with programme-controlled box. Results :EOAD exerted a definite analgesic effect on stimulation induced by physical and chemical substance and has a markedly inhibitory effect on free movement of mice . Jumping reaction and tail-erecting reaction were not found in EOAD group. Conclusion : EOAD exerts a definite analgesic and sedative action on mice and has no physical dependence.

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