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Antimicrobial properties of berberines alkaloids in Coptis chinensis Franch by micro calorimetry

文献类型:期刊文献

英文题名:Antimicrobial properties of berberines alkaloids in Coptis chinensis Franch by micro calorimetry

作者:Yan, Dan[1,2];Jin, Cheng[1];Xiao, Xiao-He[1];Dong, Xiao-Ping[2]

第一作者:Yan, Dan

机构:[1]302 Hosp Peoples Liberat Army, Inst Chinese Med, Beijing 100039, Peoples R China;[2]Chengdu Univ Tradit Chinese Med, Chengdu 610075, Peoples R China

第一机构:302 Hosp Peoples Liberat Army, Inst Chinese Med, Beijing 100039, Peoples R China

通讯机构:[1]302 Hosp Peoples Liberat Army, Inst Chinese Med, Beijing 100039, Peoples R China.

年份:2008

卷号:70

期号:6

起止页码:845-849

外文期刊名:JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS

收录:WOS:【SCI-EXPANDED(收录号:WOS:000256393200008)】;

语种:英文

外文关键词:berberines alkaloid; microcalorimetry; Escherichia coli; inhibitory effect

摘要:The growth thermogenic curves of Escherichia coli (E. coli) affected by berberine, coptisine and palmatine were determined quantitatively by microcalorimetry. The power-time curves of E. coli with and without the three berberines alkaloids (BA) were acquired, meanwhile the extent and duration of inhibitory effects on the metabolism were evaluated by growth rate constant (k), half-inhibitory ratio (IC50), peak time of maximum heat-output power (t(p)), total heat-production (Q,) and so on. The inhibitory effects of BA on E. coli revealed that the sequence of their antimicrobial activity was berberine > coptisine > palmatine. The functional groups rnethylenedioxy at C2 and C3 on phenyl ring improve antimicrobial activity more remarkably than methoxyl at C2 and C3 on phenyl ring. However, the antimicrobial activity does not vary significantly with methylenedioxy or methoxyl at C9 and C10 on phenyl ring. (c) 2007 Elsevier B.V. All rights reserved.

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