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Microstructure Abnormalities in Adolescents with Internet Addiction Disorder

文献类型:期刊文献

英文题名:Microstructure Abnormalities in Adolescents with Internet Addiction Disorder

作者:Yuan, Kai[1];Qin, Wei[1];Wang, Guihong[1,2];Zeng, Fang[3];Zhao, Liyan[4];Yang, Xuejuan[1];Liu, Peng[1];Liu, Jixin[1];Sun, Jinbo[1];von Deneen, Karen M.[1];Gong, Qiyong[5];Liu, Yijun[6,7];Tian, Jie[1,8]

第一作者:Yuan, Kai

机构:[1]Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian, Shaanxi, Peoples R China;[2]Xidian Univ, Dept Appl Math, Xian, Shaanxi, Peoples R China;[3]Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Chengdu, Sichuan, Peoples R China;[4]Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China;[5]Sichuan Univ, Dept Radiol, Ctr Med Imaging, Huaxi MR Res Ctr HMRRC,W China Hosp, Chengdu 610064, Sichuan, Peoples R China;[6]Univ Florida, Dept Psychiat, McKnight Brain Inst, Gainesville, FL 32611 USA;[7]Univ Florida, Dept Neurosci, McKnight Brain Inst, Gainesville, FL 32610 USA;[8]Chinese Acad Sci, Inst Automat, Beijing, Peoples R China

第一机构:Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian, Shaanxi, Peoples R China

通讯机构:[1]Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian, Shaanxi, Peoples R China.

年份:2011

卷号:6

期号:6

外文期刊名:PLOS ONE

收录:WOS:【SCI-EXPANDED(收录号:WOS:000291355500036)】;

基金:This paper is supported by CAS Hundred Talents Program, the National Natural Science Foundation of China under grant nos. 30970774, 60901064, 30873462, 30870685, 81000641, 81000640, 81071217, 31028010, 81071137, the Project for the National Key Basic Research and Development Program (973) under grant nos. 2011CB707700, 2011CB707702, and 863 program under grant no. 2008AA01Z411, the Fundamental Research Funds for the Central Universities. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

语种:英文

摘要:Background: Recent studies suggest that internet addiction disorder (IAD) is associated with structural abnormalities in brain gray matter. However, few studies have investigated the effects of internet addiction on the microstructural integrity of major neuronal fiber pathways, and almost no studies have assessed the microstructural changes with the duration of internet addiction. Methodology/Principal Findings: We investigated the morphology of the brain in adolescents with IAD (N = 18) using an optimized voxel-based morphometry (VBM) technique, and studied the white matter fractional anisotropy (FA) changes using the diffusion tensor imaging (DTI) method, linking these brain structural measures to the duration of IAD. We provided evidences demonstrating the multiple structural changes of the brain in IAD subjects. VBM results indicated the decreased gray matter volume in the bilateral dorsolateral prefrontal cortex (DLPFC), the supplementary motor area (SMA), the orbitofrontal cortex (OFC), the cerebellum and the left rostral ACC (rACC). DTI analysis revealed the enhanced FA value of the left posterior limb of the internal capsule (PLIC) and reduced FA value in the white matter within the right parahippocampal gyrus (PHG). Gray matter volumes of the DLPFC, rACC, SMA, and white matter FA changes of the PLIC were significantly correlated with the duration of internet addiction in the adolescents with IAD. Conclusions: Our results suggested that long-term internet addiction would result in brain structural alterations, which probably contributed to chronic dysfunction in subjects with IAD. The current study may shed further light on the potential brain effects of IAD.

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