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代谢组学在中医药复杂理论体系研究中的应用    

Application of metabonomics in complicated theory system research of traditional Chinese medicine

文献类型:期刊文献

中文题名:代谢组学在中医药复杂理论体系研究中的应用

英文题名:Application of metabonomics in complicated theory system research of traditional Chinese medicine

作者:贾伟[1];蒋健[2];刘平[2];赵立平[1];陈闽军[1];周明眉[2];杨丽萍[3];王米渠[3];邱明丰[1];张永煜[2]

第一作者:贾伟

机构:[1]上海交通大学,上海系统生物学研究所,上海200030;[2]上海中医药大学,上海201203;[3]成都中医药大学,四川成都610075

第一机构:上海交通大学,上海系统生物学研究所,上海200030

年份:2006

卷号:31

期号:8

起止页码:621-624

中文期刊名:中国中药杂志

外文期刊名:China Journal of Chinese Materia Medica

收录:MEDLINE(收录号:16830815);CSCD:【CSCD2011_2012】;北大核心:【北大核心2004】;Scopus;CSTPCD;PubMed;

语种:中文

中文关键词:代谢组学;中医药复杂理论系统;辨证论治;脏象理论;中药方剂;肠道菌群微生态学

外文关键词:metabonomics; complexed theory system of TCM; treatment based on syndrome differentiation; Zang-xiang theory; in-testinal microflora ecology

摘要:新兴学科代谢组学的出现,给中医药复杂理论体系的研究、中医药现代化提供了强有力的研究手段.中医病证引起代谢物组的共性分析和生物标记物的发现,可促进"证"本质的研究、中医辨证的科学化和定量化,深层次理解中医脏象理论,预测疾病的发生,整体性评价中药复方综合疗效、安全性和作用机制,反应肠道内生态环境状况.代谢组学和中医药学的结合,将探索出中医药复杂理论体系研究的新方法与新途径.
Metabonomies, a new and rapid-developing technology, will be powerful means to the research of complexed theory system and modernization of traditional Chinese medicine (TCM). Discovery of biomarkers and analysis of common properties from the metabolome of a specific TCM syndrome will facilitate the modernized study of TCM system, promote the quantitative and scientific elucidation of TCM syndrome differentiation, provide an in-depth understanding of the TCM theory of Zang-xiang, help predict the disease on-set, and achieve a comprehensive evaluation of systemic clinical efficacy, safety and mechanism of action of the TCM combination formulas along with a better understanding of intestinal mieroflora ecology. The new approach with combined metahnnomics and TCM methodologies will provide a new pathway and methodology for the study of complicated theory system of TCM and its modernization.

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