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Development of a poloxamer analogs/carbopol-based in situ gelling and mucoadhesive ophthalmic delivery system for puerarin

文献类型:期刊文献

英文题名:Development of a poloxamer analogs/carbopol-based in situ gelling and mucoadhesive ophthalmic delivery system for puerarin

作者:Qi, Hongyi[1];Chen, Wenwen;Huang, Chunyan;Li, Li;Chen, Chuming;Li, Wenmin;Wu, Chunjie

通讯作者:|[1063350ff6c541bbd1223]吴纯洁;

机构:[1]Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 610075, Peoples R China;[2]Beijing Qiyuan Yide Inst Materia Med, Beijing 100070, Peoples R China

第一机构:成都中医药大学药学院

通讯机构:|[106336d1d673712fc3af1]成都中医药大学药学院;[10633]成都中医药大学;

年份:2007

卷号:337

期号:1-2

起止页码:178-187

外文期刊名:INTERNATIONAL JOURNAL OF PHARMACEUTICS

收录:WOS:【SCI-EXPANDED(收录号:WOS:000247355800021)】;

语种:英文

外文关键词:ophthalmic delivery system; in situ gelling; mucoadhesive; poloxamer; carbopol; puerarin

摘要:Conventional ophthalmic solutions often eliminate rapidly after administration and cannot provide and maintain an adequate concentration of the drug in the precorneal area. To solve these problems, we developed a thermosensitive in situ gelling and mucoadhesive ophthalmic drug delivery system containing puerarin based on poloxamer analogs (21 % (w/v) poloxamer 407/5% (w/v) poloxamer 188) and carbopol (0.1% (w/v) or 0.2% (w/v) carbopol 1342P NF). The combined solutions would convert to firm gels under physiological condition and attach to the ocular mucosal surface for a relative long time. The incorporation of carbopol 1342P NF not only did not affect the pseudoplastic behavior with hysteresis of the poloxamer analogs solution and leaded to a higher shear stress at each shear rate, but also enhanced the mucoadhesive force significantly. In vitro release studies demonstrated diffusion-controlled release of puerarin from the combined solutions over a period of 8 h. In vivo evaluation (the elimination of puerarin in tear and intraocular pressure-lowering effect) indicated the combined solutions had better ability to retain drug than poloxamer analogs or carbopol alone. It appears that ocular bioavailability can be increased more readily by using the in situ gelling and mucoadhesive vehicle. (c) 2007 Elsevier B.V. All rights reserved.

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